Table 1.

Models of humanized mice

Model	Approach	Characteristics	Use
Hu-PBL-SCID (Human Peripheral Blood Lymphocyte)	Engraftment of mature PBMC obtained from blood, spleen or lymph nodes	Predominately engrafts human CD3 T cells. Study of mature T cell function	Study of mature immune cell function
Hu-SRC-SCID (Human Scid Repopulating Cell)	Engraftment of hematopoietic stem cells	Develops human hematopoietic and naïve immune systems	Study of complete hematopoietic system and naïve immune system
SCID-Hu	Engraftment of human fetal liver and thymus	Develops human hematopoietic and immune systems	Study of complete hematopoietic system and naïve immune system
Hu-Tg Mice	Transgenic expression of human genes	Expresses specific human genes in vivo	In vivo study of human gene function