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. Author manuscript; available in PMC: 2010 Jun 25.
Published in final edited form as: Cell Metab. 2009 Oct;10(4):260–272. doi: 10.1016/j.cmet.2009.08.009

Figure 7. Sustained exercise-induced and ROS-mediated insulin sensitivity in Gpx1−/− mice.

Figure 7

Chow fed 10–12 week old mice were starved overnight (12 h) and (a) ITTs (0.25 mU/g) performed, or otherwise (b–c) treadmill exercised (30 min running at 16 m/min at a 5° incline) and ITTs performed (b) immediately after or (c) after 1 h of rest. (d) Gastrocnemius muscle from exercised and 1 h rested mice injected with saline or insulin for 30 min was rapidly excised and processed for immunoblot analysis; results were quantified by densitometric analysis. (e) Mice from c were subsequently administered NAC for seven days (10 mg/L in drinking water), exercised, rested for 1 h and ITTs repeated. (f) Areas under ITT curves from c and e were determined. Results in a–f are means ± SE.