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. Author manuscript; available in PMC: 2010 Jun 25.
Published in final edited form as: Development. 2008 Nov 12;135(24):4091–4099. doi: 10.1242/dev.029330

Fig. 6. The Lrig3 mutant lateral canal truncation is rescued by removal of one copy of Ntn1.

Fig. 6

(A–F) Paintfilled E14 inner ears from transheterozygous intercross littermates. Canals (arrowheads) are normal in wild-type (A) and transheterozygous (B) embryos, while the lateral canal is truncated in Lrig3 homozygotes (C). The truncation is fully rescued when one wild type copy of Ntn1 is removed from Lrig3 homozygotes (D). Fusion does not occur in Ntn1 mutants (E) or Ntn1;Lrig3 double mutants (F). (G) Table summarizing the proportion of ears with normal, truncated, or unfused semicircular canals for each genotype in offspring from Ntn1+/−; Lrig3+/− intercrosses. The rescued population is highlighted in green. Note that the Ntn1 phenotype is not influenced by the absence of Lrig3.