Table 2.
Real-time polymerase chain reaction profile of genes involved in nitric oxide signaling and oxidative stress following late ibuprofen and indomethacin treatment in room air or 50% oxygen
| Gene | Sal-O2-L | Ibu-RA-L | Ibu-O2-L | Indo-RA-L | Indo-O2-L |
|---|---|---|---|---|---|
| CALM1 | -1.2 | -1.1 | -1.4 | -1.3 | -1.6 |
| CAV-1 | 1.8 | 1.4 | -1.3 | 1.1 | -1.3 |
| eNOS | 1.4 | -1.3 | -1.0 | -1.1 | -1.9 |
| iNOS | -1.2 | -1.2 | -1.8 | 1.5 | -1.6 |
| nNOS | -6.0 | -1.2 | -1.3 | -1.8 | 3.0 |
| Genes involved in Oxidative Stress | |||||
| CAT | -1.1 | -1.4 | -1.5 | -1.2 | -1.0 |
| GPX1 | 2.3 | 2.3 | 1.5 | 1.7 | -1.1 |
| GPX2 | -31.6 | 1.2 | 1.3 | 1.5 | 1.2 |
| GPX3 | 2.0 | 2.0 | -1.2 | 1.1 | -1.7 |
| GPX4 | 2.2 | 1.5 | 1.5 | 1.3 | 1.4 |
| GPX5 | 1.1 | -1.8 | 2.3 | -1.0 | 7.7 |
| GPX6 | 1.1 | -1.8 | 2.3 | -1.0 | 59.5 |
| GPX7 | 1.3 | 1.1 | -106.3 | -1.1 | -1.4 |
| SOD1 | 1.3 | -1.1 | 1.1 | -1.1 | -1.1 |
| SOD2 | 1.6 | 1.2 | 1.2 | 1.3 | -1.0 |
>The data are presented as fold expression difference compared to Sal-RA-E. All data were corrected using 5 different housekeeping genes. Genes are selected from a profile of 84 genes. Dowregulation is represented by parentheses and upregulation is represented by no parentheses. Genes of interest are as presented in Table 1.