Figure 9.
Multiple sequence alignment of two isoxanthopterin deaminases (Sgx9339a and Sgx9236b), two 8-oxoguanine deaminases (Pa0142 and Sgx9236e) and two guanine deaminases (E. coli guanine deaminase and guanine deaminase from humans). The 8 beta strands of the (β/α)8-barrel in Sgx9339a are denoted by the black arrows. The conserved metal binding residues and catalytic residues in all six proteins are highlighted in red, The conserved ligand binding residues in isoxanthopterin deaminase, 8-oxoguanine deaminase, and guanine deaminase are highlighted in yellow, light blue, and green, respectively. The remaining fully conserved residues in all three proteins are highlighted in dark blue.