Table 3.
rhIL21-responsive genes in whole cynomolgus monkey blood
| Gene | Average Fold Change (with IL21) | SD | P-value paired t-test |
|---|---|---|---|
| IL2RA | 4.1 | 1.76 | < 0.0001 |
| PRF1 | 1.8 | 0.78 | <0.0001 |
| IL21R | 2.3 | 0.63 | <0.0001 |
| GZMB | 1.6 | 0.39 | <0.0001 |
| IL6 | 2.7 | 1.72 | 0.0007 |
rhIL21-mediated average fold increase in RNA expression in blood of 18 individual cynomolgus monkeys stimulated in vitro for 4 hours. Control (no rhIL21) RNA expression values were normalized to 1, and p values were calculated using log2 of the fold change paired with the log2 of 1 (0).