Table 4.
Pathways significantly enriched among the genes modulated by Fludarabine in sensitive and refractory CLLs
| Significant pathways in responder patients | Significant pathways in non responder patients | |||||||
|---|---|---|---|---|---|---|---|---|
| Pathway | Number of Entities | Matched with Technology | Matched with EntityList | pValue | Number of Entities | Matched with Technology | Matched with EntityList | pValue |
| G1/S DNA Damage Checkpoints | 11 | 2 | 2 | 5.40E-04 | 11 | 2 | 1 | 4.64E-02 |
| Stabilization of p53 | 5 | 2 | 2 | 5.78E-04 | 5 | 2 | 1 | 5.08E-02 |
| p53-Dependent G1 DNA Damage Response | 7 | 2 | 2 | 5.78E-04 | 7 | 2 | 1 | 5.08E-02 |
| p53-Dependent G1/S DNA damage checkpoint | 7 | 2 | 2 | 5.78E-04 | 7 | 2 | 1 | 5.08E-02 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 9 | 3 | 2 | 1.70E-03 | ||||
| p53 signaling pathway | 14 | 11 | 3 | 1.98E-03 | ||||
| atm signaling pathway | 17 | 13 | 3 | 3.31E-03 | 17 | 13 | 2 | 4.28E-02 |
| Class I PI3K signaling events | 456 | 181 | 12 | 4.91E-03 | 456 | 181 | 10 | 1.43E-02 |
| Aurora A signaling | 117 | 43 | 5 | 5.49E-03 | ||||
| hypoxia and p53 in the cardiovascular system | 27 | 16 | 3 | 6.13E-03 | ||||
| tumor suppressor arf inhibits ribosomal biogenesis | 27 | 16 | 3 | 6.13E-03 | ||||
| inhibition of cellular proliferation by gleevec | 21 | 17 | 3 | 6.67E-03 | 21 | 17 | 2 | 5.93E-02 |
| nfkb activation by nontypeable hemophilus influenzae | 29 | 17 | 3 | 6.67E-03 | 29 | 17 | 2 | 5.93E-02 |
| TRAIL signaling pathway | 641 | 246 | 15 | 7.54E-03 | 641 | 246 | 15 | 3.24E-03 |
| IL2 signaling events mediated by PI3K | 110 | 33 | 5 | 7.73E-03 | ||||
| Activation of BH3-only proteins | 13 | 6 | 2 | 8.12E-03 | ||||
| cell cycle: g2/m checkpoint | 24 | 19 | 3 | 1.01E-02 | 24 | 19 | 2 | 8.48E-02 |
| Signaling events mediated by HDAC Class III | 44 | 21 | 3 | 1.22E-02 | 44 | 21 | 2 | 8.62E-02 |
| repression of pain sensation by the transcriptional regulator dream | 15 | 8 | 2 | 1.38E-02 | ||||
| mapkinase signaling pathway | 41 | 39 | 4 | 1.40E-02 | 41 | 39 | 3 | 7.84E-02 |
| rna polymerase iii transcription | 10 | 8 | 2 | 1.47E-02 | ||||
| Signaling events regulated by Ret tyrosine kinase | 131 | 40 | 4 | 1.61E-02 | ||||
| Signaling by Aurora kinases | 162 | 59 | 5 | 1.76E-02 | ||||
| IL2-mediated signaling events | 184 | 64 | 6 | 1.87E-02 | 184 | 64 | 5 | 6.96E-02 |
| Role of Calcineurin-dependent NFAT signaling in lymphocytes | 133 | 64 | 5 | 1.88E-02 | ||||
| oxidative stress induced gene expression via nrf2 | 16 | 10 | 2 | 2.15E-02 | ||||
| G(s)-alpha mediated events in glucagon signalling | 5 | 1 | 1 | 2.33E-02 | ||||
| Activation of PUMA and translocation to mitochondria | 1 | 1 | 1 | 2.41E-02 | ||||
| Activation of NOXA and translocation to mitochondria | 1 | 1 | 1 | 2.41E-02 | ||||
| G2/M DNA damage checkpoint | 7 | 1 | 1 | 2.41E-02 | ||||
| Intrinsic Pathway for Apoptosis | 32 | 12 | 2 | 3.05E-02 | ||||
| agrin in postsynaptic differentiation | 23 | 13 | 2 | 3.55E-02 | ||||
| cadmium induces dna synthesis and proliferation in macrophages | 37 | 13 | 2 | 3.55E-02 | ||||
| Plasma membrane estrogen receptor signaling | 547 | 217 | 11 | 3.66E-02 | 547 | 217 | 9 | 8.14E-02 |
| il-2 receptor beta chain in t cell activation | 42 | 31 | 3 | 3.77E-02 | ||||
| hypoxia-inducible factor in the cardivascular system | 26 | 14 | 2 | 4.08E-02 | ||||
| BMP receptor signaling | 329 | 163 | 9 | 4.33E-02 | 329 | 163 | 8 | 4.54E-02 |
| Class I PI3K signaling events mediated by Akt | 160 | 55 | 4 | 4.35E-02 | ||||
| rho-selective guanine exchange factor akap13 mediates stress fiber formation | 11 | 2 | 1 | 4.60E-02 | 11 | 2 | 1 | 4.64E-02 |
| FasL/CD95L signaling | 6 | 2 | 1 | 4.75E-02 | ||||
| alk in cardiac myocytes | 20 | 15 | 2 | 4.93E-02 | 20 | 15 | 3 | 6.12E-03 |
| role of mef2d in t-cell apoptosis | 31 | 15 | 2 | 5.22E-02 | 31 | 15 | 4 | 4.38E-04 |
| TNF receptor signaling pathway | 495 | 213 | 11 | 7.61E-02 | 495 | 213 | 11 | 3.77E-02 |
| integrin signaling pathway | 28 | 21 | 2 | 9.19E-02 | 28 | 21 | 3 | 1.42E-02 |
| FAS signaling pathway (CD95) | 63 | 26 | 5 | 2.99E-03 | ||||
| endocytotic role of ndk phosphins and dynamin | 22 | 6 | 2 | 7.76E-03 | ||||
| BCR signaling pathway | 94 | 52 | 5 | 8.63E-03 | ||||
| Integrins in angiogenesis | 107 | 38 | 4 | 1.18E-02 | ||||
| Alkaloid biosynthesis II | 45 | 21 | 3 | 1.81E-02 | ||||
| angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling | 39 | 24 | 3 | 1.81E-02 | ||||
| t cell receptor signaling pathway | 44 | 23 | 3 | 1.81E-02 | ||||
| links between pyk2 and map kinases | 39 | 24 | 3 | 2.02E-02 | ||||
| dicer pathway | 4 | 1 | 1 | 2.57E-02 | ||||
| AndrogenReceptor | 98 | 93 | 6 | 3.29E-02 | ||||
| Osteopontin-mediated events | 48 | 13 | 2 | 3.62E-02 | ||||
| TCR signaling in naïve CD8+ T cells | 188 | 72 | 5 | 3.66E-02 | ||||
| fas signaling pathway (cd95) | 24 | 14 | 2 | 4.16E-02 | ||||
| Ceramide signaling pathway | 90 | 55 | 5 | 4.48E-02 | ||||