Figure 4.

ROC (receiver operator characteristics) curves for the diagnosis of LINE-1 hypomethylation as a binary outcome using different cutoffs (40, 50 and 60 of 0-100 scale). Multivariate logistic regression models for the binary LINE-1 methylation outcomes were constructed using the same set of covariates as in the linear regression model. ROC curves for each cutoff was averaged over 10 folds each using 25% randomly heldout test data for cross validation. Area under the curve (AUC) represents performance characteristics of the multivariate model as a clinical test for the specific binary outcome.