Figure 8.

A simplified illustration of the topological position of the protein product of A) Essential gene (Intra-modular hub) and B) phenodiv gene (Inter-modular hub) in the molecular interaction network. The representative essential and phenodiv genes are marked in solid blue color node border. Both the classes of genes have same connectivities. Phenodiv genes have higher betweenness implying that these are proteins that occur on many shortest paths between other proteins in protein interaction network. On the other hand, essential genes have higher clustering coefficient suggesting the increased overall tendency of its interactors to form clusters.