Table 1.

Comparison of measures of centrality of specific with shared genes and phenosim with phenodiv genes in human protein interaction network

Disease gene classes	Degree		Closeness		Betweenness		Eccentricity
	Mean ± S.D.	P-value *	Mean ± S.D.	P-value *	Mean ± S.D.	P-value *	Mean ± S.D.	P-value *
Specific genes	13.29 ± 24.21	<0.001	0.26 ± 0.04	<0.01	3.3 × 10-4 ± 0.001	<0.001	8.65 ± 1.37	<0.001
Shared genes	16.28 ± 27.73		0.26 ± 0.03		5.9 × 10-4 ± 0.002		8.61 ± 1.06
Phenosim genes	12.72 ± 20.72	<0.001	0.27 ± 0.04	<0.001	3.1 × 10-4 ± 0.0007	<0.001	8.75 ± 0.88	<0.01
Phenodiv genes	20.44 ± 34.85		0.27 ± 0.04		8.7 × 10-4 ± 0.003		8.47 ± 1.17

*P-values were determined using Mann-Whitney U test