Figure 6. Cone arrestin expression in cone photoreceptors of +/+, GC1KO, AAV5-smCBA-mGC1-treated and AAV5-hGRK1-mGC1-treated mice.

Untreated GC1KO retinas contain characteristic disorganized, detached cone outer segments (B), whereas cone outer segments were intact and cone arrestin distribution appeared normal in treated GC1KO (C,D) and +/+ (A) retinal sections. All retinas were taken from mice 3 months post treatment or age matched untreated controls. Scale bar in D = 100 µm. OS-outer segments, IS-inner segments, S-synaptic terminals.