Figure 4. Myostatin inhibition increases oxygen consumption and energy expenditure in ob/ob mice.

Indirect calorimetry was performed following 6 weeks administration of vehicle (veh), GW501516, PF-879, or GW501516 in combination with PF-879 to quantify oxygen consumption (VO₂) (A) and carbon dioxide production to calculate the respiratory exchange ratio (B) and energy expenditure (C) in ob/ob mice. Data are represented as mean +/− SEM (n = 8/group). *, # and § represent p<0.05, 0.01 and 0.001, respectively.