Table 2. Paired marker analysis for HLA-DRB1*15:01 and rs4959039 haplotypes in the merged dataset.
| HLA-DRB1 | rs4959039 | N | O.R. | 95 C.I. lower | 95 C.I. upper | p-Value |
| HLA-DRB1*X | “G” | 3226 | ||||
| HLA-DRB1*15:01 | “G” | 129 | 5.89 | 3.62 | 9.59 | 1.036×10−12 |
| HLA-DRB1*15:01 | “A” | 1954 | 6.46 | 4.57 | 9.13 | 4.95×10−26 |
| HLA-DRB1*X | “A” | 216 | 1.90 | 1.35 | 2.67 | .0002 |
Two locus haplotypes were constructed and the odds ratio for association with MS susceptibility for each haplotype was tested in a logistic regression model treating each haplotype as a categorical variable. The odds ratio for the HLA-DRB1*15:01 allele in the merged dataset was 3.50 (p<1.46×10−100). All results are adjusted for stratification effects caused by sex, location (US versus UK) and dataset (discovery versus replication). DRB1*X refers to subjects who do not carry the HLA-DRB1*15:01 allele.