Figure 6.

Expression of dysregulated genes in 13‐week R6/2‐Ubc striatum. The striatal expression of dysregulated R6/2 genes was compared between the four genotypes. Although expression of all four genes was reduced in R6/2 mice as expected, the loss of one Ubc allele did not have any effect on R6/2 expression levels. Therefore, the reduction in uH2A levels in R6/2; Ubc+/− mice did not affect expression of these genes. Interestingly, expression of Darpp32 was significantly increased in the Ubc+/− striatum (P= 0.018). In addition, there was an interaction between R6/2 and Ubc genotypes (P= 0.016), which likely reflects the lack of increased Darpp32 expression in R62; Ubc+/− compared to that observed in Ubc+/−. Error bars show the standard error of the mean.