Table 3.

Relation of Central Retinal Arteriole Equivalent and Central Retinal Venule Equivalent at Baseline to Change in Renal Endpoint Models.

Dependent Variable	Independent Variable
	Central retinal arteriole equivalent per SD				Central retinal venule equivalent per SD
	Duration adjusted		Multivariatea adjusted		Duration adjusted		Multivariatea adjusted
	Est (SE)	P	Est (SE)	P	Est (SE)	P	Est (SE)	P
Change in glomerular filtration rate	−0.52 (1.15)	0.65			0.08 (1.13)	0.94
Change in albumin excretion rate	0.04 (1.39)	0.97			0.09 (1.37)	0.95
Change in mesangial fractional volume/glomerulus	0.0051 (0.0033)	0.13			0.0042 (0.0033)	0.20
Change in mesangial matrix fractional volume/glomerulus	0.0045 (0.0022)	0.04	0.0032 (0.0022)	0.14	0.0046 (0.0021)	0.03	0.0033 (0.0021)	0.13
Change in mesangial cell fractional volume/glomerulus	−0.0003 (0.0015)	0.86			0.0002 (0.0015)	0.89
Change in volume fraction of cortex which was interstitium	−0.0032 (0.0044)	0.46			0.0040 (0.0043)	0.36
Change in volume fraction cortical tubules per total tubules which were atrophic	−0.0012 (0.0036)	0.73			−0.0019 (0.0035)	0.58
Change in glomerular basement membrane width (nm)	9.30 (4.47)	0.04	7.29 (4.43)	0.10	8.06 (4.38)	0.07	5.03 (4.36)	0.25
Change in glomerulopathy index	1.38 (0.55)	0.01	1.06 (0.53)	0.05	1.27 (0.54)	0.02	0.81 (0.52)	0.12

^aFrom linear regression model.

^bMultivariate adjustment:

Change in glomerular basement membrane (GBM) width (nm): diabetes duration, glycosylated hemoglobin, sex.

Change in glomerulopathy index: diabetes duration, glycosylated hemoglobin, sex, drug trial treatment.

Change in peripheral GBM surface density/glomerulus: diabetes duration, glycosylated hemoglobin, study site.

Change in mesangial matrix fractional volume/glomerulus: diabetes duration, glycosylated hemoglobin.