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. Author manuscript; available in PMC: 2011 Jun 25.
Published in final edited form as: Circ Res. 2010 Apr 29;106(12):1882–1892. doi: 10.1161/CIRCRESAHA.109.214924

Figure 2.

Figure 2

AC6 is responsible for hyaluronan (HA) production in DASMCs. (A) PGE1 induced cAMP accumulation in DASMCs in the cells treated with negative siRNA. AC2-, AC5-and AC6-targeted siRNA decreased PGE1-induced cAMP production (n=4). (B) AC6-targeted siRNA attenuated PGE1-induced hyaluronan production, whereas AC2-and AC5-targeted siRNA did not (n=7-11). (C) Adv.AC6 enhanced PGE1-induced hyaluronan production. Adv.AC2 abolished the Adv.AC6-induced enhancement of hyaluronan production (n=4). *P<0.05 and ***P<0.001. NS: not significant.