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. Author manuscript; available in PMC: 2011 Jun 25.
Published in final edited form as: Circ Res. 2010 Apr 29;106(12):1882–1892. doi: 10.1161/CIRCRESAHA.109.214924

Figure 8.

Figure 8

The effects of FD1 and FD6 on vasodilation. (A) FD1 and FD6 similarly attenuated indomethacin-induced contraction in DA explants in a dose-dependent manner (n=4-10). (B) The whole body freezing method revealed that the rat DA opens widely after birth and closed 1 h after birth (arrow, n=5). (C) Representative images of rat DAs treated with PGE1 and FD1 using the whole body freezing method. (D) The vasodilating effects of PGE1, FD1 or FD6 were compared (n=5-7). FD1 had a longer action of duration than did PGE1. All rats injected with FD6 died 4h after injection due to apnea. Bars=1 mm. PA: pulmonary artery