Table 3.
Characterization of experimental inflammatory lesions
| Demyelination (mm−2) | AQP-4 loss (mm−2) | GFAP loss (mm−2) | C9neo deposition (mm−2) | Extracellular Col IV deposition (mm−2) | No. of split blood vessels (mm−2) | |
|---|---|---|---|---|---|---|
| LPS time course | ||||||
| LPSd0 | 0 | 0 | 0 | − | 0 | 0 |
| LPSd1 | 0 | 0.06 ± 0.01 | 0 | − | 0 | 0 |
| LPSd3 | 0 | 0.05 ± 0.01 | 0 | − | 0 | 0.5 ± 0.3 |
| LPSd5 | 0.06 ± 0.02 | 0.12 ± 0.02 | 0.023 ± 0.01 | − | 0.01 ± 0.01 | 1.3 ± 0.8 |
| LPSd8 | 0.16 ± 0.02 | 0.2 ± 0.02 | 0.07 ± 0.01 | − | 0.06 ± 0.01 | 2.8 ± 0.5 |
| LPSd12 | 0.51 ± 0.02 | 0.24 ± 0.02 | 0.15 ± 0.02 | − | 0.11 ± 0.01 | 7.5 ± 1.8 |
| LPSd15 | 0.29 ± 0.01 | 0.33 ± 0.01 | 0.16 ± 0.02 | − | 0.15 ± 0.01 | 9.8 ± 3.8 |
| Saline | 0 | 0 | 0 | − | 0 | 0 |
| EAE time course | ||||||
| EAEd0 | 0 | 0 | 0 | − | 0 | 0 |
| EAEd3 | 0 | 0 | 0 | − | 0 | 0.43 ± 0.3 |
| EAEd6 | 0 | 0 | 0 | − | 0 | 6.6 ± 1 |
| EAEd9 | 0 | 0 | 0 | − | 0 | 5.14 ± 0.6 |
| EAEd12 | 0 | 0 | 0 | − | 0 | 1.9 ± 0.5 |
| EAEd15 | 0 | 0 | 0 | − | 0 | 0.14 ± 0.1 |
| EAE + MOG (d1) | 0.09 ± 0.03 | 0 | 0 | +++ | 0 | 0 |
| EAE + NMO (d1) | 0.028 ± 0.005 | 0.57 ± 0.11 | 0.25 ± 0.1 | +++ | 0 | 0 |
| EAE + C Ig (d1) | 0 | 0 | 0 | − | 0 | 0 |