Fig. 6.

Quantification of QC-expressing neurons and pE-Aβ deposits in normal human brain and in AD. The highest proportion of QC-immunoreactive neurons in control subjects was detected in the NbM, followed by LC and EWN. In all brain regions analysed, there was a reduction of the neuronal number in AD as identified by expression of Ucn-1/ChAT, TH and ChAT, respectively (* p < 0.05). While in control subjects no pE-Aβ deposits were detected in any of the brain nuclei investigated, a significant number of pE-Aβ deposits was detected in AD brains. Both, neuronal loss and formation of pE-Aβ deposits was most pronounced in NbM