. Author manuscript; available in PMC: 2011 Dec 1.

Published in final edited form as: Biochim Biophys Acta. 2010 Feb 12;1802(12):1259–1267. doi: 10.1016/j.bbadis.2010.02.004

Table 1.

G protein-coupled receptor kinases involved in specific dopamine receptor signaling.

Dopamine Receptor Subtype	G protein-coupled receptor kinase	References
D₁R (in differentiated kidney cells) (in embryonic kidney cells)	GRK2, GRK4 (GRK4α and GRK4γ in humans^#, GRK4E in rats) GRK2, GRK3, GRK4α but not GRK4γ, GRK5^*	53, 112, 121–123 113, 114
(in intestines but not kidney cells)	GRK6	120, 124
D₂R	GRK2, GRK3, GRK5, GRK6	73, 148, 149
D₃R (in kidney cells)	GRK2, GRK3, GRK4γ>GRK4α	129, 151
D₄R	GRK2 or GRK3^?	73
D₅R	^?

GRK5 increased agonist-dependent phosphorylation of rat D₁R one report (114), but not in another report (113). GRK4α and GRK4γ desensitize the human D₁R (112) while GRK4α but not GRKγ desensitizes the rat D₁R (113).

?unknown or not definite