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. Author manuscript; available in PMC: 2010 Jun 27.
Published in final edited form as: Int J Immunopathol Pharmacol. 2007 Apr–Jun;20(2):373–380. doi: 10.1177/039463200702000218

Fig. 1. The novel PV-associated SEREX antigen, MPD5, is an unconventional antigen.

Fig. 1

A. A schematic representation of the location of the unconventional antigen, MPD5, in the complementary (i.e., antisense) strand within the intron 1 region of the NEK6 (NIMA-6) gene (GenBank accession number: NT_00847016). B. The structure of MPD5 promoter and the structure of MPD5 mRNA transcript. MPD5 has an ORF of 144 bp (GenBank accession number: AY567967). Four interferon regulatory factor 1 (IRF-1) binding sites—including NF-KB, AP1, and other transcription factor binding sites—were found in the 2kb region of the MPD5 promoter. These results suggest that MPD5 transcription may be regulated by interferon-α stimulation. C. The in vitro transcription and translation product of MPD5. D. The protein sequence of MPD5. E. The hydrophilicity index plot of MPD5, analyzed by the Kyte-Doolittle method, suggests that there are hydrophilic regions within the N-terminal and C-terminal regions of MPD5.