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. 1997 Oct 1;17(19):7532–7540. doi: 10.1523/JNEUROSCI.17-19-07532.1997

Fig. 5.

Fig. 5.

Diazepam enhancement of GABAR currents in dentate granule cells from control animals and in cells isolated from rats after 45 min of seizures. Diazepam at 300 nm enhanced GABAR current in dentate granule cells from control animals but did not enhance current in cells isolated from rats after 45 min of seizures. The traces are from two different neurons.Horizontal bars showed the duration of application of the drug. A, Diazepam (300 nm) was applied with 10 μm GABA to a dentate granule cell from a control animal. B, Diazepam (300 nm) was applied with 6 μm GABA to a granule cell isolated from a rat after status epilepticus. A lower concentration of GABA was used to compensate for a small leftward shift of the GABA concentration–response curve in cells from animals undergoing status epilepticus (equipotent GABA concentration).