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Preferred sites of commensal/probiotic interaction with the gut. Cecum/ascending colon is a “bioreactor” with the greatest amounts of bacteria, metabolic activity, and SCFA fermentation. Concentration of SCFA diminishes along the colon. The distal ileum is enriched in GALT (Peyer's patches) and is the dominant site of luminal sampling and mucosal adaptive immune activity.
