Table 1.
Table of all Coxiella burnetii seroreactive antigens identified by protein microarray. The horizontal bold line separates differentially reactive antigens from cross-reactive antigens. Numbers listed under “Beare et al” indicate the seroreactivity rank for each antigen previously identified by Beare et al [18].
| LocusTag | Gene Symbol |
Product Description | Predicted subcellular location |
transmembrane domains |
Signal Peptide |
Average Infected |
Average Naïve |
p-value | Beare et al. identified |
|---|---|---|---|---|---|---|---|---|---|
| CBU1910 | com1 | 27kDa outer membrane protein | Unknown | 1 | + | 25816 | 1188 | 5.E-08 | |
| CBU0891 | hypothetical protein, conserved | Unknown | 2 | + | 19264 | 4844 | 2.E-04 | 1 | |
| CBU0109 | lipoprotein | Unknown | 0 | + | 15517 | 5872 | 4.E-03 | ||
| CBU1143 | yajC | preprotein translocase, YajC subunit | Unknown | 1 | + | 14235 | 759 | 2.E-04 | 3 |
| CBU0612 | ompH | Outer membrane protein | OuterMembrane | 1 | + | 13159 | 4178 | 1.E-02 | 2 |
| CBU0092 | ygbF | tol-pal system protein YbgF | Unknown | 0 | + | 10437 | 537 | 4.E-04 | |
| CBU0545 | lemA | LemA protein | Unknown | 1 | - | 8402 | 1388 | 3.E-03 | 5 |
| CBU1398 | sucB | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase |
Cytoplasmic | 0 | - | 8193 | 633 | 2.E-03 | 4 |
| CBU0630 | mip | Outer membrane protein MIP precursor | OuterMembrane | 0 | + | 7481 | 917 | 7.E-03 | |
| CBU1513 | short chain dehydrogenase | Cytoplasmic | 0 | + | 6576 | 788 | 1.E-02 | ||
| CBU1719 | groES | Chaperonin protein Cpn10 | Cytoplasmic | 0 | - | 4720 | 1040 | 9.E-03 | |
| CBU0229 | rplL | ribosomal protein L7/L12 | Unknown | 0 | - | 3570 | 904 | 5.E-02 | |
| CBU0653 | hypothetical protein, conserved | Unknown | 0 | - | 3473 | 926 | 4.E-02 | ||
|
| |||||||||
| CBU1627 | lcmE | IcmE protein | Unknown | 1 | + | 13708 | 7228 | 5.E-02 | |
| CBU1863 | Hypothetical protein, conserved | CytoplasmicMembrane | 4 | - | 5168 | 1765 | 8.E-02 | ||
| CBU1094 | efflux transporter, RND family, MFP subunit | CytoplasmicMembrane | 1 | + | 5016 | 2895 | 1.E-01 | ||
| CBU0895 | Hypothetical protein | Unknown | 1 | - | 4186 | 4981 | 8.E-01 | ||
| CBU1386 | rpsB | ribosomal protein S2 | Unknown | 0 | - | 3886 | 2207 | 4.E-01 | |
| CBU1768 | Hypothetical protein | Unknown | 2 | + | 3544 | 3609 | 1.E+00 | ||
| CBU0615 | lpxA | acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | Cytoplasmic | 0 | - | 3514 | 4855 | 6.E-01 | |
| CBU0436 | t-snare protein, family | Unknown | 2 | - | 3475 | 2762 | 6.E-01 | ||