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. Author manuscript; available in PMC: 2011 Mar 14.
Published in final edited form as: Structure. 2010 Mar 14;18(4):436–448. doi: 10.1016/j.str.2010.01.013

Figure 9. Model for HAMP Domain Signal Transduction.

Figure 9

Schematic of a ligand dependent, two-state (A and B) HAMP domain signal transduction model highlighting the movement and rotation of helices in a canonical HAMP system and a poly-HAMP system. In the poly-HAMP system successive AS1 helices are contiguous with the preceding AS2 helices. HAMP domain structural rearrangements correspond to a change in helical register, helix-helix crossing angle, and helix rotation. Asterisks denote stutters within HAMP domains. Signal input is shown as a symmetric and downward piston-like displacement of transmembrane helix 2 (TM2), but both an asymmetric displacement or a helical rotation of TM2 would likely lead to the same conformational changes within HAMP domains.