Table 2. Relative Threading Scores for HAMP Sequences onto Known Conformations.
Numbers refer to the Rosetta Design Score, given in Rosetta Energy Units (REUs), with lower scores being more stable. The lowest stable score is highlighted in grey for each conformation in our two-state model.
Protein Sequences | Conformations | |||
---|---|---|---|---|
HAMP1 | HAMP2 | HAMP3 | Af1503 | |
Hamp1 | 38 | 2047 | 1347 | 5510 |
Hamp2 | 358 | -74 | 2792 | 1001 |
Hamp3 | 1555 | 564 | 145 | 2599 |
Af1503 | 1085 | 304 | 1667 | 148 |
Aer | 2016 | 613 | 1615 | 6773 |
Mt Rv3645 | 212 | 506 | 937 | 4616 |
NarX | 1757 | 416 | 490 | 1298 |
Tar | 1985 | 486 | 431 | 3000 |
Tsr | 1606 | 459 | 255 | 885 |