Table 2. Protein Polymer Contrast Agent Properties with Varying Lysine Spacing and Molecular Weight of 22 kDa.
K4-30 | K6-40 | K8-30 | |
---|---|---|---|
Average # of Gd(III) per molecule | 14.5 | 11.5 | 8.0 |
# of Lysines per protein | 61 | 41 | 31 |
Protein molar mass (kDa) | 22.1 | 21.7 | 21.7 |
Conjugation efficiency (%) | 23.9 | 28.0 | 26.7 |
Relaxivity per Gd(III) (mM-1s-1) | 12.1 | 9.1 | 8.8 |
Relaxivity per molecule (mM-1s-1) | 175.4 | 104.7 | 70.5 |