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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Curr HIV Res. 2009 Nov;7(6):639–649. doi: 10.2174/157016209789973682

Figure 2.

Figure 2

Semiquantitative pathology analysis of vaginal tissues at study days 4, 7, and 11. Rabbit vagina sections were evaluated microscopically after treatment with CMC vehicle alone, gel containing 2% N-9, gel containing 8% N-9, 0.5% BZK, or 2% BZK. Exudate, leukocyte infiltration, erosion, hemorrhage, decreased epithelial height, edema, and fibrosis were scored by a four step system: not observed, 0; minimal, 1; mild, 2; moderate, 3; and marked, 4. The cumulative scores of these parameters are shown at sacrifice days 4, 7, and 11 for one representative experiment (n=3) with 5 animals per group. Data were analyzed by the Kruskal-Wallis test (**: p<0.01; ***: p<0.001).