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Effect of SERCA inhibition on somatodendritic DA release. a, Average [DA]o versus time profiles in the SNc evoked by local stimulation (30 pulses, 10 Hz) in the absence and presence of a membrane-permeable SERCA inhibitor, CPA (30 μm, n = 6). b, Summary of the effect of CPA on peak [DA]o; control peak [DA]o was taken as 100%. Inhibition of SERCA by CPA decreased evoked [DA]o (n = 6, **p < 0.01 vs control), demonstrating the involvement of ER Ca2+ stores in somatodendritic DA release.
