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. 2010 Jun 9;133(7):2032–2044. doi: 10.1093/brain/awq132

Figure 2.

Figure 2

Accumulation of SNARE proteins in the striatum of α-syn(1-120) mice. Immunohistochemistry for SNARE proteins in the striatum of 18-month-old α-syn(1-120) mice and control mice shows accumulation of SNAP-25 (B), syntaxin-1 (D) and synaptobrevin-2 (F) in transgenic but not in control mice (A, C, E). α-Syn(1-120E) mice also show accumulation of SNAP-25 (H) unlike C57BL/6J mice (G). The difference in SNAP-25 staining between 6-month-old α-syn(1-120) mice (J) and C57BL/6S controls (I) is much less pronounced. No significant differences were present in the expression of SNARE proteins between transgenic mice and controls (K). Scale bars = 20 µm.