Skip to main content
. 2010 Jun 9;133(7):2032–2044. doi: 10.1093/brain/awq132

Figure 6.

Figure 6

SNARE protein staining in transgenic mouse models of human neurodegenerative diseases. Staining of cerebral cortex from mice transgenic for human mutant A30P α-synuclein for SNAP-25 (A) and syntaxin-1 (B) shows a similar accumulation of SNARE proteins as in mice transgenic for α-syn(1-120). Staining of cerebral cortex from mice transgenic for human mutant P301S tau for SNAP-25 (C) and syntaxin-1 (D) shows a pattern distinct from that of the mouse lines transgenic for α-synuclein. No accumulation of SNAP-25 (E) or syntaxin-1 (F) was observed in the striatum from transgenic mice expressing human mutant huntingtin (line R6/2). Scale bars = 20 µm.