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. Author manuscript; available in PMC: 2011 Jun 16.
Published in final edited form as: J Am Chem Soc. 2010 Jun 16;132(23):7838–7839. doi: 10.1021/ja101677r

Figure 3.

Figure 3

Targeting of QDs to A431 (squamous cancer) cells using norbornene-tetrazine cycloaddition. Top: QD fluorescence at 605 nm with excitation at 488 nm. Bottom: corresponding DIC images (scale bar 10 μm). Cells were targeted either by (B) using preformed QD-EGF complexes (50 nM) for single QD tracking or by (D) performing in situ conjugation using norbornene-functionalized QDs (800 nM) on BATEGF- modified cell surfaces for ensemble labeling. (A) and (C) are control experiment with poly(PEG12)-PIL QDs (without norbornene).