Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
BIG 1-98 trial design. The design accommodated its genesis as a two-arm trial that evolved into a four-arm trial enabling both head-to-head comparison of letrozole vs tamoxifen as well as assessment of the role of sequential endocrine therapies.
