Table 2. Stepwise Linear Regression: Multivariable correlates of log Lp-PLA2 Activity and Mass (n=7989).
| Activity | Mass | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable, unit | β | 95% CI | P value | Partial R2, % | β | 95% CI | P value | Partial R2, % |
| Covariates forced in | ||||||||
| Age, per 10 years | 0.007 | 0.002, 0.01 | 0.003 | 0.05 | 0.02 | 0.01, 0.02 | <0.0001 | 0.28 |
| Women vs. men | -0.11 | -0.12, -0.10 | <0.0001 | 3.02 | -0.06 | -0.08, -0.05 | <0.0001 | 0.83 |
| Offspring Cohort (reference) | -- | -- | <0.0001 | 11.53 | -- | -- | <0.0001 | 8.4 |
| Generation 3 | 0.17 | 0.16, 0.18 | -0.21 | -0.23, -0.19 | ||||
| Omni wave 1 | -0.18 | -0.20, -0.16 | -0.28 | -0.31, -0.26 | ||||
| Omni wave 2 | -0.13 | -0.15, -0.11 | -0.29 | -0.32, -0.26 | ||||
| Covariates selected by model | ||||||||
| Current smoking, yes/no | 0.04 | 0.02, 0.05 | <0.0001 | 0.21 | 0.08 | 0.06, 0.09 | <0.0001 | 0.76 |
| Alcohol drinks/week | ||||||||
| 1-7 women; 1-14 men | -0.009 | -0.02, 0.00004 | 0.0008 | 0.08 | -0.03 | -0.04, -0.01 | 0.0004 | 0.14 |
| >7 women; >14 men | -0.02 | -0.04, -0.01 | -0.03 | -0.04, -0.009 | ||||
| Body mass index, per 5kg/m² | -0.01 | -0.01, -0.007 | <0.0001 | 0.16 | -- | -- | -- | -- |
| Diastolic blood pressure, per 20 mm Hg | -- | -- | -- | -- | 0.006 | 0.0003, 0.01 | 0.04 | 0.04 |
| Log-triglycerides | -0.03 | -0.04, -0.03 | <0.0001 | 0.76 | -- | -- | -- | -- |
| Log-LDL-cholesterol | 0.37 | 0.35, 0.38 | <0.0001 | 14.32 | 0.20 | 0.18, 0.21 | <0.0001 | 3.54 |
| Log-HDL-cholesterol | -0.31 | -0.33, -0.29 | <0.0001 | 6.40 | 0.02 | -0.0004, 0.05 | 0.0004 | 0.11 |
| Cardiovascular disease, yes/no | 0.02 | 0.002, 0.04 | 0.03 | 0.02 | -- | -- | -- | -- |
| Hypertension medications, yes/no | -0.02 | -0.03, -0.009 | 0.0003 | 0.07 | -0.02 | -0.04, -0.007 | 0.004 | 0.08 |
| Lipid medications, yes/no | -0.03 | -0.04, -0.01 | <0.0001 | 0.10 | -0.08 | -0.10, -0.06 | <0.0001 | 0.74 |
| Hormone replacement therapy, yes/no | -0.06 | -0.07, -0.04 | <0.0001 | 0.30 | -0.08 | -0.10, -0.06 | <0.0001 | 0.57 |
| Season (vs. Winter) | ||||||||
| Spring | -0.009 | -0.021, 0.001 | 0.0005 | 0.09 | -0.002 | -0.02, 0.01 | <0.0001 | 0.25 |
| Summer | -0.0004 | -0.01, 0.01 | 0.03 | 0.01, 0.05 | ||||
| Fall | 0.01 | 0.002, 0.02 | -0.004 | -0.02, 0.01 | ||||
| Model R2 | 57.4 | 27.5 | ||||||
See methods section for candidate covariates for stepwise selection. Cholesterol concentrations were log-transformed, triglycerides were log-normalized for analysis.