TABLE 3. Association of inflammatory candidate gene SNPs and multivariable-adjusted log Lp-PLA₂ in Offspring cohort (n=1535)^*.

Allelic Variant	Gene	Protein Gene Codes for	Chr*	Location	Major→ Minor Allele	MAF	Beta heterozygotes	SE	Beta homozygotes minor allele	SE	R2	P-Value	q-Value
rs2033547	MEF2A	myocyte enhancer factor 2A	15	980324	A|T	46.1	0.12	0.06	-0.15	0.08	1.0	3.20*10-4	0.25
rs1029153	CXCL12	chemokine (C-X-C motif) ligand 12	10	441871	A|G	26.7	-0.20	0.06	0.12	0.11	1.0	3.44*10-4	0.25
rs10520358	VEGFC	vascular endothelial growth factor C	4	1779630	C|T	10.8	0.13	0.07	-0.90	0.27	1.0	5.12*10-4	0.25
rs6019910	PTGIS	prostaglandin I2 synthase	20	476230	C|T	6.7	-0.08	0.08	-1.16	0.31	1.0	5.14*10-4	0.25
rs193276	CD44	CD44 molecule (Indian blood group)	11	35140414	T|C	23.6	-0.02	0.06	0.47	0.13	0.9	1.21*10-3	0.31
rs1051931	PLA2G7	phospholipase A2, group VII	6	46780902	A|G	19.4	0.21	0.06	0.21	0.15	0.9	1.26*10-3	0.31
rs10520358	VEGFC	vascular endothelial growth factor C	4	1779630	C|T	10.8	-0.01	0.08	-1.17	0.31	0.9	9.14*10-4	0.96
rs4335431	TGFB2*	transforming growth factor, β 2	1	2149460	T|C	7.5	0.26	0.09	-0.85	0.38	0.9	1.26*10-3	0.96
rs12058490	TGFB2*		1	2149476	A|G	7.9	0.24	0.09	-0.85	0.38	0.9	1.45*10-3	0.96
rs10128001	PTGER3	prostaglandin E receptor 3	1	712568	C|T	8.6	-0.26	0.09	-0.58	0.34	0.8	2.89*10-3	0.99
rs17038663	CX3CR1	chemokine (C-X3-C motif) receptor 1	3	392803	C|T	5.9	0.31	0.10	-0.29	0.70	0.7	3.29*10-3	0.99

^*Lp-PLA₂ activity and mass adjusted for 19 covariates (see methods for details).

Q values were calculated within phenotype.

Partial R² refers to the proportion of multivariable-adjusted Lp-PLA₂ value explained by the specific SNP.

^*TGFB2 LD r²=0.95