Skip to main content
. Author manuscript; available in PMC: 2010 Jun 28.
Published in final edited form as: J Immunol. 2008 Dec 15;181(12):8258–8266. doi: 10.4049/jimmunol.181.12.8258

Figure 1. The IgG anti-protein and anti-polysaccharide response to Pn14 is CD28-dependent.

Figure 1

WT (C57BL/6) and CD28-/- mice (7 per group) were immunized i.p. and then boosted on day 14 with either (A) Pn14 in saline or (B) PPS14-PspA + C-PS-PspA in alum/CpG-ODN. Serum titers of antigen-specific IgM and IgG are illustrated for day 0 (“pre-immune”) and day 21 (“immune”). *significant, p<0.05 between WT and CD28-/- mice.