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. Author manuscript; available in PMC: 2010 Jun 28.
Published in final edited form as: J Immunol. 2008 Dec 15;181(12):8258–8266. doi: 10.4049/jimmunol.181.12.8258

Figure 2. The IgG anti-PPS14 and anti-PC response to Pn14, in contrast to pneumococcal conjugate, is ICOS-independent.

Figure 2

WT (C57BL/6) and ICOS-/- mice (7 per group) were immunized i.p. and then boosted on day 42 with either (A) Pn14 in saline or (B) PPS14-PspA + C-PS-PspA in alum/CpG-ODN. C) WT (C57BL/6) and ICOS-/- mice (7 per group) were immunized i.p. with Pn14 in saline and then boosted on days 14 and 21. Serum titers of antigen-specific IgM and IgG are illustrated. *significant, p<0.05 between WT and ICOS-/- mice.