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. Author manuscript; available in PMC: 2010 Jun 28.
Published in final edited form as: J Immunol. 2008 Dec 15;181(12):8258–8266. doi: 10.4049/jimmunol.181.12.8258

Figure 3. ICOS costimulation for induction of the IgG anti-PspA response to Pn14 is critical during primary, but not secondary immunization.

Figure 3

BALB/c mice (7 per group) were immunized i.p. with Pn14 in saline and boosted on day 42. Anti-ICOSL mAb (clone HK5.3) or a control rat IgG2a anti-E coli β-galactosidase mAb (clone GL117) [1 mg per mouse] were injected on day 0 and/or day 42. Serum titers of antigen-specific IgM and IgG are illustrated. *significant, p<0.05 between control mAb and anti-ICOSL mAb.