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. Author manuscript; available in PMC: 2010 Jun 28.
Published in final edited form as: J Immunol. 2008 Dec 15;181(12):8258–8266. doi: 10.4049/jimmunol.181.12.8258

Figure 5. Protein- and polysaccharide-specific IgG responses to both Pn14 and conjugate are defective in SAP-/- mice, whereas the IgM anti-polysaccharide response is differentially regulated in response to the two immunogens.

Figure 5

WT (C57BL/6) and SAP-/- mice (7 per group) were immunized i.p. with either (A) Pn14 in saline (boosted on day 21) or (B) PPS14-PspA + C-PS-PspA in alum/CpG-ODN (boosted on days 21 and 35). Serum titers of antigen-specific IgM and IgG are illustrated. *significant, p<0.05 between WT and SAP-/- mice.