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. 2010 Jun 9;30(23):7984–7992. doi: 10.1523/JNEUROSCI.1244-10.2010

Figure 6.

Figure 6.

Overexpression of Homer1c in the NAcore attenuated reinstatement of cocaine seeking. A, There was no difference in extinction learning between Homer1c-AAV- and GFP-AAV-infected animals when the AAVs were administered 1 d before the initiation of extinction training. B, There was no difference in extinction learning between Homer1c- and GFP-infected animals when the AAVs were infused 2 weeks before initiating extinction training. C, Homer1c-AAV infection immediately before extinction training attenuated cue-primed reinstatement. A two-way ANOVA with repeated measures over trial (i.e., extinction and cue-prime) confirms significant main effects of virus (F(1,18) = 5.68; p = 0.028) and trial (F(1,18) = 20.00; p < 0.001), as well as interaction (F(1,18) = 4.22; p = 0.054). D, Homer1c-AAV infection followed by 2 weeks of abstinence before extinction training attenuated cue-primed reinstatement. A two-way ANOVA revealed significant main effects of virus (F(1,13) = 7.43; p = 0.017) and trial (F(1,13) = 28.90; p < 0.001), as well as a significant interaction (F(1,13) = 6.37; p = 0.025). E, Immune staining of HA-tagged Homer1c reveals cellular labeling 5 weeks after virus infusion into the NAcore. ac, Anterior commissure. *p < 0.05, compared with extinction; +p < 0.05, comparing Homer-AAV to GFP-AAV, using a least significant difference post hoc test (Milliken and Johnson, 1984). Error bars indicate SEM.