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. Author manuscript; available in PMC: 2010 Jun 28.
Published in final edited form as: Thromb Haemost. 2005 Jul;94(1):167–174. doi: 10.1267/THRO05010167

FIG. 7.

FIG. 7

Orderly phases of wound healing and the effects of salivary components. Wound healing is divided in three phases: inflammatory (inflammation), proliferative (granulation tissue), and remodeling (wound contraction) phases. Salivary molecules Ixolaris (7), Penthalaris (18), SALP14 (19), ISAC (20), a salivary inhibitor of neutrophil function (6, 21), and a bradykinin-degrading kininase (22)—work in concert to effectively block the acute phase of inflammation. Later stages of inflammation, during which endothelial cell-dependent granulation tissue formation takes place, appear to be counteracted by tick salivary components displaying anti-angiogenesis activities. Modified from R. A. Clark, 1991 (50).