Table 2.
Baseline serum biochemical and hormonal variables and GFR, estimated by the endogenous creatinine clearance calculated by the Schwartz formula (11), in both groups of patients
| Variable | Untreated Group (n = 7) | GH-Treated Group (n = 7) |
|---|---|---|
| Creatinine (μmol/L) | 174.0 ± 49.7 | 281.2 ± 104.4 |
| GFR (ml/min per 1.73 m2) | 27.8 ± 7.9 | 23.0 ± 6.3 |
| BUN (mmol/L) | 10.5 ± 3.0 | 25.9 ± 7.8 |
| Calcium (mmol/L) | 2.36 ± 0.19 | 2.26 ± 0.35 |
| Phosphate (mmol/L) | 1.95 ± 0.28 | 1.69 ± 0.19 |
| Intact PTH (pg/ml) | 221.1 ± 110.2 | 333.1 ± 179.8 |
| Bicarbonate (mmol/L) | 24.3 ± 1.2 | 22.4 ± 0.9 |
| Insulin (pmol/L) | 63.4 ± 30.1 | 70.7 ± 30.1 |
| Total IGF-I (ng/ml) | 121.3 ± 23.3 | 89.4 ± 25.6 |
| Total IGF-I SDS | −0.73 ± 0.12 | −0.86 ± 0.13 |
| Free IGF-I (ng/ml) | 0.34 ± 0.05 | 0.39 ± 0.10 |
| Free IGF-I SDS | −0.06 ± 0.41 | 0.50 ± 0.76 |
| IGF-II (ng/ml) | 684.0 ± 75.2 | 624.4 ± 79.4 |
| IGF-II SDS | 1.04 ± 0.63 | 0.70 ± 0.64 |
| IGFBP-1 (ng/ml) | 127.0 ± 20.3 | 98.7 ± 23.9 |
| IGFBP-1 SDS | 6.87 ± 1.19 | 5.19 ± 1.41 |
| IGFBP-2 (ng/ml) | 3207.9 ± 578.9 | 3012.4 ± 495.9 |
| IGFBP-2 SDS | 19.24 ± 3.89 | 18.15 ± 3.04 |
| IGFBP-3 (μg/ml) | 3.41 ± 0.51 | 2.94 ± 0.37 |
| IGFBP-3 SDS | 0.08 ± 0.47 | −0.26 ± 0.32 |
| GHBP (pmol/L) | 474.1 ± 161.1 | 546.1 ± 127.1 |
| GHBP SDS | −1.42 ± 0.36 | −1.26 ± 0.28 |
| Ghrelin (pg/ml) | 1606.3 ± 239.0 | 1556.4 ± 239.0 |
| Ghrelin SDS | 0.85 ± 0.91 | 0.81 ± 0.54 |
| Leptin (ng/ml) | 11.60 ± 3.64 | 11.50 ± 5.39 |
| Leptin SDS | 3.77 ± 2.15 | 3.77 ± 3.18 |
Data are means ± SEM. There were no statistically significant differences between groups for any of the analyzed variables. BUN, blood urea nitrogen; PTH, parathyroid hormone.