Figure 1.

Pedigrees of five MSK families with GDNF sequence variations, showing how the altered alleles cosegregate with the disease. Filled symbols identify individuals with MSK. Asterisks indicate heterozygous carriers of the variants (the simple allele with the c.−27+18G>A variant alone in families A, B, and C, and the complex allele comprising the c.−45G>C and the c.−27+18G>A sequence variations in families D and E). The arrows highlight the probands. Automated GDNF gene sequencing shows the nucleotide substitutions, identified by the arrow.