Table 2.
Association statistics for CCR2-V64I genotypes for cases and SIL positive controls
| SIL positive controls (n = 91) | Cases (n = 446) | |||||
|---|---|---|---|---|---|---|
| Black 31 (34) | Mixed-ancestry 60 (66) | Black 106 (24) | Mixed-ancestry 340 (76) | Genotype-cervical cancer association, adjusted for ethnicity and smoking | ||
| Genotypes | n (%) | n (%) | n (%) | n (%) | P-value | OR (95% CI) |
| CCR2 G→A | ||||||
| GG | 21 (68) | 40 (66) | 24 (23) | 78 (23) | - | 1 |
| AG | 9 (29) | 19 (32) | 81 (76) | 255 (75) | 0.001 | 7.18 (4.35-11.87) |
| AA | 1 (3) | 1 (2) | 1 (1) | 7 (2) | 0.300 | 2.32 (0.47-11.36) |
| AG + AA | 10 (32) | 20 (33) | 82 (77) | 262 (77) | 0.001 | 6.86 (4.19-11.21) |
Cases = Women with cancer of the cervix (ICC), SIL positive controls = Women without cancer of the cervix (ICC) but positive for LSIL and HSIL by pap smear test.