Table 3.
Association statistics for CCR2-V64I genotypes according to cytology in the control group
| Normal cytology (n = 1070) | Abnormal cytology (n = 185) | |||||
|---|---|---|---|---|---|---|
| Black 210 (20) | Mixed-ancestry 860 (80) | Black 64 (35) | Mixed-ancestry 121 (65) | Genotype-abnormal cytology association, adjusted for ethnicity and smoking | ||
| Genotypes | n (%) | n (%) | n (%) | n (%) | P-value | OR (95% CI) |
| CCR2 G→A | ||||||
| GG | 124 (59) | 563 (66) | 45 (70) | 78 (64) | - | 1 |
| AG | 84 (40) | 287 (33) | 17 (27) | 40 (33) | 0.290 | 0.83 (0.59-1.17) |
| AA | 2 (1) | 10 (1) | 2 (3) | 3 (3) | 0.134 | 2.28 (0.78-6.69) |
| AG + AA | 86 (41) | 297 (35) | 19 (30) | 43 (36) | 0.437 | 0.88 (0.63-1.22) |
Abnormal cytology = Positive for pap smear test (i.e. positive for ASCUS + positive for LSIL + positive for HSIL), Normal cytology = Negative for pap smear test.