Figure 2. Induction of lethality in mice by intestinal E. coli-derived OMVs.

Mice were administered intraperitoneally once with 200 µl PBS that contained 0, 15, 25, or 50 µg OMVs derived from E. coli. Survival was monitored every 12 h for 5 days (n = 20; ***P<0.001, compared to the PBS group).