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. 2010 Jun 28;5(6):e11334. doi: 10.1371/journal.pone.0011334

Figure 3. Induction of SIRS signs in mice by intestinal E. coli-derived OMVs.

Figure 3

A. Study protocol for investigation of SIRS. Sublethal dose of OMVs (5 µg) derived from E. coli was injected intraperitoneally three times at 12-h intervals, and the mice were checked for SIRS index. All experiments in (B–E) were performed following this scheme using 5 µg OMVs derived from E. coli. B. Piloerection (left) and eye exudates (right). C and D. Body temperature (C) and respiratory rate (D) examined after OMVs injection (n = 5; **P<0.01 and ***P<0.001, compared to the PBS group). E. Leukocyte number in blood collected from mice after OMV injection (n = 5; ***P<0.001, compared to the 0 h group).