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. 2010 Jun 28;5(6):e11334. doi: 10.1371/journal.pone.0011334

Figure 4. Induction of lung dysfunction, disseminated intravascular coagulation and hypotension in mice by intestinal E. coli-derived OMVs.

Figure 4

A and B. Bronchoalveolar lavage fluid and lung organs were prepared from mice injected with OMVs derived from E. coli following Fig. 3A. The total number of leukocytes in bronchoalveolar lavage fluid (A) and wet-to-dry ratio of the lungs (B) (n = 5; *P<0.05, **P<0.01, and ***P<0.001, compared to the 0 h group). C and D. Measurement of the number of platelets in peripheral blood (C) and D-dimer levels in plasma (D) after OMV injection, as indicated in Fig. 3A (n = 5; **P<0.01 and ***P<0.001, compared to the 0 h group). E. Systolic blood pressure examined after OMV injection (n = 5; *P<0.05, compared to the PBS group).