Sequences were evolved with each residue having a fixed probability of changing to another residue per time step as described in the Materials and Methods. Positions were placed in groups of 2 (), 4 (□), 5 (◊), or 10 () and constrained to coevolve with likelihoods of 0.1, 0.25, 0.5, 0.75 and 0.95. For example, if the group size was 4 and the likelihood of coevolution was 0.25, then if the residue of one member of the group was changed during the time step, then each of the other three members of the group was allowed to change to another residue with the fixed probability given on the X axis. The Y axis shows the mean score for each group size and each probability for 10 replicate in silico evolution runs.