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Cardiac function in the aerobically perfused ex vivo working mouse heart
| Genotype | +/+ | −/− |
|---|---|---|
| Heart Rate (beats • min−1) | 285 ± 9 | 246 ± 17* |
| Rate pressure product (bpm • mmHg • 10−3) | 20 ± 0.5 | 18 ± 0.9 |
| Cardiac Work (ml • mmHg • min−1) | 6.5 ± 0.3 | 4.2 ± 0.6** |
| Cardiac Output (ml/min) | 9.3 ± 0.4 | 5.8 ± 0.7** |
| Aortic Output (ml/min) | 7.1 ± 0.4 | 3.7 ± 0.8** |
| Cardiac Power (mjoules • min-1) | 71.6 ± 3.3 | 47.6 ± 7.0** |
Values are mean ± SEM, n = 7–17,
P <0.05 vs. control,
P <0.01 vs. control
